In Shinjuku ward's east side lies Kabukichou, a vibrant city of chaos that glows brilliantly with neon lights but also hides unseen darkness. Employed at a university hospital on the west side, John H. Watson is looking for someone who can assist him with an odd case. His search leads him to the Pipe Cat, an underground bar that serves as a meetup venue and job board for some of the best detectives in Shinjuku, the most prominent among them being Sherlock Holmes. Upon finding the bar and meeting the peculiar investigators, John learns that they are pursuing a case involving Jack the Ripper, an infamous serial killer. Due to subsequent events, John ends up driving Sherlock to the crime scene of a murder supposedly carried out by Jack the Ripper. Even though John is only there to enlist Sherlock's help with his case, he witnesses Sherlock brilliantly uncover the truth behind the crime scene. However, he begins to realize that Sherlock is not only a genius detective but also an eccentric character. As John continues to request Sherlock to assist him with his case, he finds himself spiraling into the detective lifestyle of solving cases beyond the minds of ordinary civilians. Through this work, John begins to see the true colors of the chaotic city that is Kabukichou and starts to unravel the unsettling mystery behind his own case.

After being inspired by the fictional anime, "Luis Monde III", Mikiko "Kuromi" Oguro goes to animation school and and finally lands the job of her dreams at Studio Petit. Upon arriving, she meets the head of production. Unfortunately for her, he dies soon after meeting her and passes his position unto her. Now that she's head of production of "Time Journeys", it's up to her to rally up the lazy animator's and finish the second episode in a week.

By the 19th century, humanity has cultivated technology enabling the reanimation of corpses. Unable to experience individual thoughts or emotions, the corpses are programmed by humans to act as laborers in various occupations. This newfound technology, however, comes with a catch. Science may be able to restore the corpses' ability to move, yet it cannot return what every corpse loses at death: the soul. But Doctor Victor Frankenstein, who vanished shortly after his revolutionary work on corpse reanimation, is said to have revived the only corpse in possession of a soul. In pursuit of this scientific knowledge, London medical student John Watson hopes to fulfill his promise to his late partner, Friday. After being scouted by a government agency, Watson is on a hunt to obtain Frankenstein's notes, which he believes hold the key to the secrets of the soul. During his search, Watson uncovers the harsh realities of the developing corpse technology and the price he must pay to advance his research. [Written by MAL Rewrite]

Shiki Toono sustained a life threatening injury as a child, and due to that incident he was sent away from the Toono household and was given to a relative to be raised. Years later, when Shiki is in high school, the head of the Toono household—his father—dies, and he is ordered to move back in by his sister Akiha, who is the new head of the household. However, Shiki holds a huge secret. Ever since that injury, he has been seeing lines on objects, and only with a special pair of glasses is he able to stop seeing them. Also he is unable to remember anything well from the time before his accident. The day he moves back to the Toono household is the day he stumbles upon a woman named Arcueid Brunstud and decapitates her with one stab of his knife in a temporary fit of insanity. When she suddenly showed up beside him later alive and well, and ask him to be her bodyguard, Shiki's journey to unravel the mysteries of his past begins. (Source: ANN)