Rentarou Aijou has it all: looks, intelligence, athletic skill, and popularity with peers and mentors alike. Unfortunately, none of these qualities help Rentarou with his love life. On the day of his middle school graduation, he is once again turned down by a girl he confesses to, earning his one-hundredth rejection in a row. Down on his luck, he goes to a matchmaking shrine and wishes to finally get a girlfriend in high school. When the god of the shrine suddenly appears before him, Rentarou is told he will meet an astronomical total of one hundred soulmates in high school. Though Rentarou initially does not take this foretelling seriously, his doubts disappear when, on the first day of school, he meets two of these soulmates—Hakari Hanazono and Karane Inda—who both confess to him. With fated encounters and love confessions galore, Rentarou's life is about to get a lot more exciting.

Following the awakening of her Dream-Sight ability, Miyo Saimori reunites with her fiancé, Kiyoka Kudou, the captain of the special forces protecting the country against ill-intended individuals gifted with exceptional powers. However, the couple's blissful life is suddenly interrupted when Takaihito, the top contender for the imperial throne, sends Kiyoka on a dangerous mission. Traveling with Miyo to the remote household of his parents, Kiyoka must investigate unusual reports of demons in the region. Meanwhile, Miyo tries to gain the approbation of her callous mother-in-law, Fuyu, who refuses to recognize her as a family member. After Kiyoka repels an attack by the Gifted Communion, a subversive sect of special abilities wielders, he returns to the capital alongside his fiancée. As the looming threat against the imperial authority intensifies, Kiyoka must thwart the Gifted Communion's plans to protect Miyo and everyone he holds dear.

The name Tarou Sakamoto once instilled fear in every villain. No other professional hitman matched his prowess, and fellow assassins revered him. However, Sakamoto fell in love. In five short years, he married, became a father, put on some weight, and traded his weapons for an apron as he became the owner of a humble convenience store. Although Sakamoto is decidedly retired, he finds his old life of crime hard to shake off. His former partner, Shin Asakura, reappears and resolves to stay with Sakamoto's family under their strict no-kill rule. To make matters worse, a large bounty is placed on Sakamoto's head. Numerous assassins now pursue him—but they are in for a surprise. Sakamoto has not lost his edge, and no matter what tricks his enemies pull, he will fight off every last one to protect his dear family.

Having resolved the crisis in the Petrification Kingdom, Senkuu and his companions gear up to deal directly with the mastermind behind the petrification phenomenon—who supposedly resides on the moon. The ambitious spaceship project, however, requires immense manpower and critical resources scattered across the world. Thus, the Kingdom of Science exploration team kick-starts its transcontinental journey on the ship Perseus to gather them all. Equipped with modern technology and bolstered by the new, capable members in their ranks, the exploration team feels confident about setting sail to their first destination: America. They soon realize that the region now hosts adversaries controlling the resources they need, doing so with scientific technology which rivals and even exceeds their own. In a battle of science versus science, Senkuu and his team must outsmart their rivals if they are to have any chance of ensuring the continued survival and rejuvenation of humanity.