After a successful showdown at Tokyo Tower, the Mew Mew girls enjoy a temporary respite. Now that Ichigo Momomiya and Masaya Aoyama have confessed their feelings to each other, Ichigo is overjoyed to spend time with her new boyfriend. However, their quick break gets interrupted, and soon the girls must battle against the Chimera Anima yet again. When things go awry in the ensuing fight, Ichigo is placed in grave danger. Just when things look most bleak, the mysterious Blue Knight arrives and saves Ichigo, proclaiming that he was born to protect her, before disappearing into thin air. With the fate of the world on their shoulders and the identity of the Blue Knight in question, the Mew Mew girls must strive to create balance between alien-fighting and their personal lives.

Tetsuhiro Morinaga is in love with his upperclassman Souichi Tatsumi. He even manages to confess his love. Too bad it turns out that Tatsumi is an aggressive, self-centered, and outspoken homophobe. Yet somehow Tetsuhiro managed to fall in love with Tatsumi, the “walking personality disorder,” who is the kind of man who declares that all gay men should be wiped off the face of the planet. An unfortunate accident with an aphrodisiac drug brings the two men physically together against Souichi’s will. The experience has a life-changing effect on both men. But will it ultimately bring them closer, or drive them apart?

Tousuke Rokudou is a first-year attending Aomori High, a school full of delinquents. He is often bullied by his classmates due to his incompatibility with their behavior, the only exceptions being his two good friends who are also social outcasts. Frustrated at the way they are treated, the three wish they could stand up and claim the fun, peaceful school life of their dreams. However, Tousuke's life takes a drastic turn when he receives a package from his late grandfather containing their family heirloom, a scroll said to possess the power to save him from impending danger. Upon holding the scroll, a sudden glow emanates, leaving a strange mark on Tousuke's forehead. Thinking that he's received the means to free himself and his friends from their daily treatment, Tousuke is shocked to find out that its effects are far different than what he had imagined. Although his bullying continues, he realizes that the mark from the scroll acts as a charm, capturing the hearts of delinquent girls—in particular, Ranna Himawari, the strongest of them all.

When Hayato's grandmother passed, he planned to sell her rundown café on the shore—not realizing that it was also home to five young women who call themselves her family?! Their desperation to keep the café open convinces Hayato to give it a shot...but even their best intentions might not be enough to make it work! And can he even work with these five unruly women? No matter what, he's got his work cut out for him!