Sometime in the distant future, mankind is forced to live in domed cities while the rest of the world is left to recover from years of environmental hardships. In the Siberian Dome-polis, professional gamer Gainer Sanga and mercenary Gain Bijou commandeer an Overman and lead a mass exodus out of the city.

In 2059, five decades after the Space War I conflict seen in the first Macross story. Macross Frontier, the 25th New Macross Class super-long-distance colonization fleet, is journeying through the galaxy to a new paradise to call home. However, it is locked in a state of war with a strange enemy called Vajra. Macross FB7 is the 30th anniversary work of the Macross franchise.

In deep space a battle wages between the forces of good and evil and the fate of the Earth hangs in the balance. The evil Neos Gold dispatches her invading forces towards Earth with only one aim: the total destruction of all mankind. Now it's up to Iczer 3 (the younger sister of Iczer 1) to defend the Earth from the deadly armada of Neos Gold, with only the Earth's single remaining battle cruiser on her side. But don't count her out; what Iczer 3 lacks in experience she makes up for in all-out enthusiasm.

The time is the near future. Cockroaches and other household pests have become immune to all forms of insecticides. In response to this crisis, a Japanese company has created small, doll-like, insect exterminating robots called Hoi Hoi-san. A competing company has also released their own version, Combat-san. Because of their adorable appearance, these little robots have become somewhat of a phenomenon and have gained many fans. Late at night, in the home of one such fan, Hoi Hoi-san and Combat-san search for insects to exterminate... but Combat-san is not above trying to exterminate Hoi Hoi-san while she's at it.