On the planet Noman's Land, reporters Meryl Stryfe and Roberto De Niro traverse the desert in search of the infamous outlaw Vash the Stampede. But the man they find near the desolate town of Jeneora Rock is a far cry from the lethal terrorist they expect. In reality, Vash is a passive and carefree drifter; he is a proponent of peace, beloved by the residents of the town. His inaccurate reputation actually stems from the widespread atrocities committed by his twin brother Knives Millions. Still, Vash is dubbed "The Humanoid Typhoon'' due to the tendency for violent chaos to follow in his wake. Chaos soon arrives in the form of bounty hunters seeking the high price on Vash's head, and their violent pursuit poses great danger to the town and its precious power plant. Thanks to his gunslinging prowess, Vash is able to resist most of these nefarious forces. Yet he must soon face off against the ultimate evil: the unstoppable destructive power of his malevolent brother.

Yoichi Isagi was mere moments away from scoring a goal that would have sent his high school soccer team to the nationals, but a split-second decision to pass the ball to his teammate cost him that reality. Bitter, confused, and disappointed, Isagi wonders if the outcome would have been different had he not made the pass. When the young striker returns home, an invitation from the Japan Football Union awaits him. Through an arbitrary and biased decision-making process, Isagi is one of three hundred U-18 strikers selected for a controversial project named Blue Lock. The project's ultimate goal is to turn one of the selected players into the star striker for the Japanese national team. To find the best participant, each diamond in the rough must compete against others through a series of solo and team competitions to rise to the top. Putting aside his ethical objections to the project, Isagi feels compelled to fight his way to the top, even if it means ruthlessly crushing the dreams of 299 aspiring young strikers.

Unable to achieve the desired results on the first and second days of the Inter-High competition, members of the Souhoku High Bicycle Racing Club use their frustration as motivation to perform better on the final day of the race. However, it is easier said than done as they are up against the overwhelming talent of Hakone Academy and the shrewd strategies of Kyoto Fushimi High. Despite the challenge, Souhoku members are not disheartened by the obstacles that they need to overcome. After all, no matter what their opponents try, Souhoku will have the last laugh as long as they are the first to cross the finish line.

Dralc, a vampire who is feared as he is rumored to be invincible. The vampire hunter Ronaldo goes to Dralc's castle after hearing that Dralc has kidnapped a child. But when Ronaldo arrives at the castle, he finds that Dralc keeps dying over every small thing and turning to dust. Dralc's true nature is that of the weakest vampire of them all.