The anime will feature an original story from the game on which it is based.

Based on COLOPL's school action role-playing game. Set in the year 2045. The world has been contaminated by Irousu (mysterious invaders who suddenly appeared), and humans find themselves restricted and contained. Standing boldly against these invaders are ordinary girls everywhere, without a powerful army or even weapons. The Shinjugamine Girls Academy is a school for these "Hoshimori" (Star Guardians) destined to fight the Irousu. The player is assigned to this academy to train the girls and take back the contaminated Earth. And so, once again, the chimes echo through the sun-strewn schoolyard to mark the beginning of classes today...

Aichi and his friends have won the National Tournament and decide to go their own ways until a mysterious boy named Takuto Tatsunagi appears. He reveals that the Royal Paladins, Dark Paladins, and Kagero leaders have been captured, and the only way to free Cray is for the Vanguard fighters to use a new power- Limit Break. Because the Royal Paladins lose the ability to fight, Aichi's deck is changed to be a Gold Paladin deck. Aichi and his friends must now win the Vanguard VF Circuit if they are to learn more about the occurrences on Cray and free their old friends. (Source: ANN)

An animated series created to celebrate 25 years of the global entertainment franchise. Each episode will take fans on a journey through all the known regions of the Pokémon world.