In deep space a battle wages between the forces of good and evil and the fate of the Earth hangs in the balance. The evil Neos Gold dispatches her invading forces towards Earth with only one aim: the total destruction of all mankind. Now it's up to Iczer 3 (the younger sister of Iczer 1) to defend the Earth from the deadly armada of Neos Gold, with only the Earth's single remaining battle cruiser on her side. But don't count her out; what Iczer 3 lacks in experience she makes up for in all-out enthusiasm.

After living in Transylvania for several years, "Earl Dracula" (as Osamu Tezuka's official website calls him in English) has moved to Japan. In the Nerima Ward of Tokyo, he and his daughter, Chocola, and faithful servant Igor have taken up residence in an old-Western style house. While Chocola attends Junior High School, Earl Dracula is desperate to drink the blood of beautiful virgin women; an appropriate meal for a vampire of his stature. However, each night that Earl Dracula goes out on the prowl he finds himself getting involved in some kind of disturbance which leads to him causing various trouble for the local residents. With nobody in Japan believing in vampires, his very presence causes trouble amongst the people in town.