Wisteria is an orphan girl living in a corner of the British Empire at the end of the 19th century. Her life is desolate and bleak–until she encounters Marbas, a powerful but equally lonely immortal being with a furry appearance, hounded by hunters. Together, Wisteria and Marbas roam the Empire–populated by humans and human-like beasts–in search of a place where they can live together in peace.

With a stray pitch that completely missed the batter, Eijun Sawamura loses his final middle school baseball game. Frustrated by this defeat, Eijun and his teammates vow to reach the national tournament once they are in high school. But everything changes when a scout unexpectedly invites him to Tokyo's prestigious Seidou High School after seeing the potential in his unusual pitching style. Encouraged by his teammates, Eijun accepts the offer, ready to improve his skills and play at a much more competitive level of baseball. However, now surrounded by a large number of skilled players, Eijun struggles to find his place on the team. He declares that he will one day become the team's ace, but that's only if fellow first year Satoru Furuya doesn't take the title first, with his breakneck fastballs that earn him a coveted spot on the starting roster. With the addition of these talented new players to an already powerful lineup, the Seidou baseball team aims to become the best in Japan, facing off against a number of formidable foes that stand in their way. [Written by MAL Rewrite]

Nen: the hidden source of energy and potential that runs through everyone, and gives those that master it a source of great power. Inside Nen is the potential for limitless light and limitless darkness. The Hunter Association has arisen to control access to it. Hunters come in many shapes and forms, and with many different appetites - but all of them have learned to master Nen, and use it to chase wealth, power, and their dreams. The greatest and most powerful Hunter is Isaac Netero, chairman of the Hunter Association. Decades ago he sealed away Jed, a Hunter who had mastered the use of On, the dark "shadow" of Nen. Now On users have reappeared at the Heaven's Arena "Battle Olympia" tournament. For Netero, this is the last mission: to protect the Association and the world from a threat driven by hatred and the thirst for revenge. And he's going to need all the help he can get in order to succeed.

Suletta Mercury leaves her planet and enters the Asticassia School of Technology at the behest of her mother. There, right and wrong are determined through duels between students, and the top-ranking duelist will receive Miorine Rembran as their fiancée—this prize being decided by Miorine's father. When Guel Jeturk, the best pilot in school and Miorine's current fiancé, demands that his betrothed move in with him, Suletta disapproves, so Guel challenges her. Although she emerges as champion, Suletta is subsequently detained on suspicion of piloting a forbidden type of mobile suit—a GUND-ARM, or "Gundam"—which results in her victory being voided. Miorine refuses to accept any more injustices and proposes another duel with even higher stakes. Now, Suletta must triumph a second time, otherwise she will be expelled and the Gundam Aerial that means so much to her will be destroyed.