Life hasn't been kind to Zenos. He was born in the slums, and his dirt-poor background has denied him almost every opportunity. After an encounter with a healer, he throws himself into studying to become one and finally catches a break when an adventurer invites Zenos into his party. Zenos is thrilled—so thrilled, in fact, that he's willing to put up with his teammates treating him like garbage. They fail to appreciate his talents and ultimately kick him to the curb, claiming he's outlived his usefulness to them. Now bereft of money and out of options, Zenos decides to put his self-taught skills to use elsewhere and opens an underground clinic. Word quickly spreads about the brilliant healer working incredible magic in the city's shadowy underbelly. Even the royal palace is taking notice... Can Zenos buck the odds and carve out a life for himself in a world that's spit in his face? And can he save the lives of the patients who wind up on his doorstep in the process?

After seeing enough death and tragedy, the immortal Fushi secludes himself on an island, defending himself from enemy Nokkers. However, instead of attacking Fushi in isolation, Nokkers begin targeting the settlements outside of his reach in hopes of luring him out. Soon, a group known as the Guardians—led by Hisame, the descendant of the deceased warrior Hayase—finds Fushi. Inspired by how Fushi protected Janada Island from the Nokkers years ago, the Guardians have grown a considerable following and are recognized throughout the world. Initially reluctant, Fushi allows the Guardians to accompany him to the site of the Nokkers' recent attack. In their village, Fushi meets a few valuable allies, both new and old. But as the conflict with the Nokkers only leads to more loss, Fushi must find the inner strength to face his inevitable sorrow.

Demons have now become commonplace around the kingdom of Midland, which has fallen into chaos. The swordsman Guts still cannot stay in one place for long due to his demonic brand. He could always manage to protect himself when he was alone, but now he has the added challenge of protecting former Commander Casca, a shell of her former self who neither remembers nor trusts him. They never have a moment's rest with the constant threat of demons, and they need a place where Casca will be safe till they find a way to heal her. Their elf ally, Puck, tells of the mystical land of Elfhelm, which is supposed to be a safe haven from the demons that ravage the lands. Tired and with only a vague hope, they struggle on to find a place to live—and they still need to find those responsible for the madness they are forced to endure. [Written by MAL Rewrite]

Allen, a misanthropic wizard, lives deep within the forest. He is known as the "Demon Lord" and feared by those around him. One day, while living his life as a hermit, he comes across a young girl named Charlotte who has collapsed in the forest. Despite being innocent, she was accused of evil deeds, had her engagement annulled, and was forced to flee her country. When he heard that, Allen remembered the agony of being betrayed by a group he once thought was his companions. After hearing the story of the 17-year-old's exploitation, Allen decides, "I'll let her live in my mansion, and I'll teach her all sorts of bad things..."