Second season of Komi Can't Communication. On her first day attending the elite Itan Private High School, Shouko Komi immediately receives an overwhelming surge in popularity due to the unprecedented stoic beauty and refined elegance her classmates perceive her to possess. However, only Hitohito Tadano, an exceedingly average schoolboy who sits next to her, discovers that behind her bishōjo appearance, Komi has a severe communication disorder. Subsequently, Tadano resolves to help Komi reach her goal of 100 friends.

Long ago, a goddess descended from Heaven and blessed the desolate land of Gatepia. As a result, gigantic gates appeared, leading to dungeons abundant in "kirakuri," crystals containing the energy needed for the foundation of the world. This led to the formation of various companies of adventurers who would harvest kirakuri from the dungeons. Following his father's disappearance inside one of the biggest gates in Gatepia, Minato is urged by his childhood friend Yutoria to become the president of his father's treasure-hunting company—the Kibou Company. He reluctantly agrees and meets with the other employees: the priest Makoto, the soldier Akari, and the accountant Guide. Thus, Makoto begins his tenure as president. As he and his comrades strive to fulfill various missions and other assorted tasks in order to keep their small company alive, they will uncover the mystery behind their former leader's sudden departure.

After fending off the threat of a Neuroi invasion of Romagna and destroying the enemy's nest over Venezia, Yoshika Miyafuji goes back to her home town in the Empire of Fusou. Despite the loss of her magical and healing abilities, the former officer of the 501st Joint Fighter Wing wants to continue studying medicine. This is in order to help those in need, both civilians and those on the front lines alike. She receives an invitation from a prestigious school in Europe and decides to accept the offer, embarking on a journey back to the war-torn continent. However, a new danger arises, as more and more Neuroi manage to break through human defense lines, appearing unnoticed in supposedly safe areas and disturbing the balance of power in Europe. Yoshiki's sense of duty collides with her inability to pilot a Striker Unit, but with her friends in peril, it seems that there is only one thing she can do.

Each episode follows Fukuzou Moguro, a traveling salesman, and his current customer. Moguro deals in things that give his customers their heart's desire, and once his deals are made and their unhealthy desires are satisfied, Moguro's customers are often left with terrible repercussions, especially if they break the rules of his deals...