Satou has been in love with his childhood friend and neighbor, Hime, ever since she and her grandfather appeared out of nowhere 10 years ago. Now a dazzling, yet mysterious high school beauty, she makes it more and more difficult for him to confess his feelings. As the anniversary of their first meeting is nearing, will he muster up his courage to transform their friendship into something more? Or will an entirely different fate await this tightly bonded pair?

After his high school graduation, Yuuki Wakura realizes it has been five years since his sister's disappearance during a "Mato disaster." Throughout Japan, mysterious entrances have opened to a dimension called "Mato"—a demonic metropolis filled with disastrous monsters known as the "Shuuki" that threaten the safety of humans. However, a new hope arose, as the discovery of a Mato fruit that grants supernatural abilities exclusively to women allowed them to fight against the Shuuki. Due to this, a new matriarchal government was formed, establishing a female organization called the Anti-Demon Corps, which caused men to fall to the bottom of society. When Yuuki suddenly finds himself in Mato, he is unable to escape on his own. But just as he anticipates a gruesome end by the Shuuki, a girl in a militia outfit appears and protects him. As the chief of the Seventh Unit of the Anti-Demon Corps, Kyouka Uzen is ambitious yet devalued by her own peers due to her power being deemed unusual. Now in a life-or-death situation, Kyouka takes the opportunity to find out the true potential of her superpower by using Yuuki: in order to defeat the Shuuki, he has to become her slave.

Hiiragi Utena has always looked up to magical girls and fantasized about transforming into a cool heroine who fights evil. So, when a doll-like figure approaches her one evening, claiming that she has magical power lying dormant within, she trembles in excitement. But her colorful dream is quickly shattered in an ironic turn of events when she transforms into a villain! Disinterested in associating with the forces of evil, she tries to quit when a group of magical girls appear and declare war. A battle ensues and Hiiragi soon discovers that she enjoys inflicting pain on others as her true nature starts to emerge. Mahou Shoujo ni Akogarete follows Hiiragi as she begins her new life as the leader of villains, fighting against magical girls and indulging in her newfound sadistic nature to her heart's content.

In the near future, after a nuclear explosion has caused the Earth to collide with Hell, elementary student Kento finds a small daemon creature named Anna and raises her. The series follows the adventures of Kento and Anna as they embark on a journey to rescue his mother.