Blue Gender takes place in the not too distant future in a world where things have gone terribly wrong for humanity. Humans have been replaced at the top of the food chain by the Blue, a race of bug-like aliens that have colonized Earth and pushed humans aside. A space station, Second Earth, has been constructed as a safe haven for humans, with the hope of one day reclaiming the Earth once more. Yuji Kaido was cryogenically frozen, having been suffering from a disease known as B-Cells. Once awakened, he joins a team of soldiers that have come to Earth to extract him. Unfortunately, nothing goes according to plan as they make their way back to Second Earth. Yuji will have to deal with the horrors of fighting a bloody war as he and the fighters from Second Earth look to survive. Will they be able to win back Earth without losing their humanity?

Teppei is going to visit his older brother Kotaro Takamiya during a scientific conference after training with a mysterious woman named Karen for the past 11 years. However his plans for a family reunion become stalled when a woman named Aramis kills everyone in the conference to kidnap Kotaro. Teppei on the way to save his brother encounters a broken mechanical horse called B't X who revives thanks to Teppei's blood and is now his aide to save his brother from the mysterious Machine Empire.

Home to countless street acts and performances, Veludo Way attracts those interested in watching professional actors. After receiving a mysterious letter, Izumi Tachibana arrives at the venue where her father directed a once-popular theater group, Mankai Company, but learns that the building is about to be repurposed due to excessive debt. At the last minute, she convinces the debt collector to give the ensemble one more chance. He is willing to accept but on three conditions: their debut show must be successfully produced by the following month, the four all-male sub-troupes must be reinstated, and the debt must be paid off within a year. To top it off, Izumi herself must become the director. With no time to lose, Izumi quickly gathers five people for the Spring Troupe: Sakuya Sakuma, an enthusiastic high school student; Masumi Usui, a boy infatuated with Izumi; Tsuzuru Minagi, an aspiring playwright; Itaru Chigasaki, a mature office worker; and Citron, a friendly foreigner. Though they have little or no experience in acting, it's up to Izumi to train and prepare them for a performance that will restore Mankai Company to its former glory.

Souzou Haran was a brilliant scientist that was conducting research on Mars. He created a form of cyborg life with the ability to think for itself. These cyborgs, dubbed the Meganoids, soon ran out of control and killed Dr. Haran along with his whole family, save his youngest son, the 16-year-old Banjou Haran. Banjou escapes from Mars on a rocket with a solar-powered super robot called Daitarn 3, which was built with the special metals of Mars. Now eighteen years old and living on Earth in a luxurious mansion, Banjou fights against the Meganoids with the aid of his faithful butler Garrison and his two gorgeous companions Reika and Beauty. Together they must stop the evil Meganoids which aspire to turn all humans into cyborgs and thus "improve" the human race. (Source: AniDB)