Despite having a good reputation as one of the most seasoned guards in the local guild of Mebuki, Kikuru Madan believes he has been wasting his youth and hopes to spend the rest of it like any other person. However, his conscience prevents him from retiring at present, as he worries about the guild's future without him. Coincidentally—as if to help him find his successor—the guild's receptionist, Enome, assigns Kikuru four fresh recruits: the energetic beastwoman Hitamu "Hitamuki" Kyan, the prodigy Maidena Ange, the laid-back Toxico Dannar, and the stalwart Hanabata Nohkins. Although each of them possesses significant talents, they also display characteristics that detract from their potential—including Hitamu's extreme clumsiness and Hanabata's unintentional perverseness. As if there was not enough to deal with, the monsters outside Mebuki's walls start exhibiting odd behavior by targeting women salaciously, causing the party endless problems in more ways than one. Nevertheless, Kikuru is committed to retiring early; to achieve his goal, the guidance he gives the trainees will be absolutely essential.

The Fourth Industrial Revolution has led to the development of cutting-edge technologies that have rapidly evolved the world. As a result, schools have begun incorporating these technologies into their curriculum, leaving behind the ways of the old. One such institution is the elite Yuyu Girls' Vocational High School, where both Serufu Yua and her childhood friend, Miku "Purin" Suride, have applied. Although the tech-savvy Purin is accepted to Yuyu High, the accident-prone Serufu is rejected and enters the traditional Gatagata Girls' High School instead, driving a wedge into their friendship. On her way to class one day, Serufu gets into a bike accident, and Rei Yasaku, a passerby who attends the same school, fixes her damaged bicycle. Serufu later finds out that Rei has a passion for old-fashioned crafts and is the head of the school's Do-It-Yourself (DIY) Club—which is in danger of closing due to a lack of members. Realizing that this may be her chance to repair her relationship with Purin, Serufu joins the club in hopes of creating projects that could bring them together once more. As the DIY Club welcomes new faces, Serufu learns to build not only handicrafts but also new friendships along the way!

High school girl duo Popuko and Pipimi are back and more unhinged than ever after their initial efforts to create a full-fledged anime production were met with a great reception. With no regard for their audience, they continue to live their reckless everyday lives consisting of comedy skits and parodies of epic proportions. No one is immune to the effects of their antics—including hapless live actor Shouta Aoi, who is on the run and stuck trying to be a hero in the wrong series.

In the future, the moon is a habitable place with atmosphere and gravity and also a famous tourist attraction. There are also stories about a "long ears" creature like rabbits on the moon who can use magic. Haruka Daichi heads off to the moon during a summer holiday alone because he likes to see the long ears creature by himself. However, he get himself dragged into an ancient conflict between two ancient moon races: the "long ears" race and Jado race. Jado race wanted to conquer the universe and resurrect ancient evil powers to seize control of the Earth. Now the "long ears" race and Daichi must seek three warriors who could use magic to release Mado King to fight Jado race and to release "long ears" race's kingdom, Rabiluna, from Jado race.