Sasahara Natsuki is a poor bounty hunter in a world where monsters and humans live together. Most of her cases involve monsters infringing upon the rights of humans, who are protected by law from their generally more powerful neighbors. Being half-human and half cat-beast, Natsuki straddles the two societies and tries to understand and respect both while enforcing the law. She is assisted by a werewolf named Batanen who is afraid to admit he loves her; another werewolf named Tommy; and a Kyubi fox demon named Sakura who has her own plans--which include eating Natsuki to complete her her nine tails and thereby her magical powers.

Amawa Hibiki is a young man just out of college, with an education to be an athletics teacher. He's been having a hard time finding a job since he graduated, so all his money has gone towards living expenses. When his landlady demands his first payment to live in her living establishment upfront, he heads to the local middle school to get hired as a teacher. However, the principal refuses to hire him without hesitation. She will not hire men as teachers and makes it clear that she hates all men, saying they put no love into their passions and work. Amawa does not give up and with the help of his landlady, he crossdresses as a woman without a second thought, and gets hired, so he can earn money and also prove the principal wrong. Now, he has to keep his real gender a secret, and avoid strange situations, including the affections of his students (from both genders).

The innocent Nagomi Wahira has always admired the cute girls serving at maid cafes. Hoping to fulfill her dream of becoming one, she moves to Akihabara to work at the maid cafe Ton Tokoton. Nagomi's first day seems completely normal—until she has to run an "errand" at a rival maid cafe along with her fellow recruit, the mature Ranko Mannen. There, things quickly go south, and Nagomi soon gets her first taste of Akihabara's violent maid wars. As she watches Ranko calmly battle her way through a horde of gun- and knife-wielding maids, Nagomi realizes that maid cafes are drastically unlike what she had envisioned. While struggling to reconcile her expectations with the harsh reality she finds herself in, Nagomi searches for the enjoyment she once saw in the lives of maids.

How did this young boy become notorious gentleman thief "Lupin III"? Loosely based on Young Lupin III from the original manga, will tell a nostalgic, yet brand new original story, finally lifting the veil cast upon Lupin III's humble beginnings. Set during the era in which the original series was first published, the anime depicts Young Lupin III running around the streets of 1960's Japan during the country's economic boom. A young boy climbs the staircase to villainhood. What was he thinking and what steps did he take? This is the untold origin story of the world's greatest thief.