My Melody arrives on Earth much to the surprise of her rival Kuromi. Together with one of the junior high school students, Yumeno Uta, they decide to protect the dreams of the people with the help of magic.

A continuation of Onegai My Melody.

The story is set in Aquafall, a fantasy world abound with water and greenery, and populated by dragons and fairies. Meteorites suddenly bring forth evil creatures that threaten all living things on the planet. The fairy Syrup assembles the Aquafall Defense Force, with three girls of the dragon clans as recruits. The story follows Syrup and the dragon girls Leviathan, Bahamut, and Jörmungandr as they work together to battle enemies and grow up.

Yuu, Persia, Mai and Yumi are together in a science fiction-like adventure. An awful monster assault young and beautiful girls, leaving them transformed into ugly hags: only our four magical girls with their powers can fly to the space and fight for Earth 's sake, so Yuu transforms into Creamy Mami, Mai into Magical Emi, Persia into Fairy and little Yumi draws space suits for all of them.