In the world of Remnant, humans and Faunus—human-animal hybrids—carry on their everyday lives despite the omnipresent threat of the monstrous Grimm. Dedicated Huntsmen and Huntresses battle Grimm with both customized weapons and their own "Semblances," unique abilities derived from the energy of one's soul. Some warriors also utilize a crystallized energy propellant, "Dust," to bestow their weapons with elemental properties. In this dangerous line of work, rigorous training is required to stay alive. To that end, each of Remnant's four Kingdoms have established schools to properly groom children holding aspirations of becoming licensed Huntsmen. At Beacon Academy in the Kingdom of Vale, a promising group of future Huntresses make their debut as Team RWBY. Ruby Rose, Weiss Schnee, Blake Belladonna, and Yang Xiao Long each come from different backgrounds and often butt heads as a result. However, when they cooperate, they are a formidable force who have even attracted the attention of Beacon's headmaster Professor Ozpin. Alongside fellow students such as those in Team JNPR, the young prodigy Ruby and her friends engage in adventures which pit them against an extremist Faunus group known as the White Fang. Every explosive encounter also brings them closer to the true villains orchestrating conflicts from the shadows.

Broadcasting club member Shihono Kobayashi always gushes to her friend Aoto Endou about MagiKoi, an otome game where protagonist Fiene attends the Royal Academy of Magic. But despite the colorful cast, the one character Kobayashi is most obsessed with is the villainess Lieselotte Riefenstahl. Contrary to her rude remarks toward Fiene, Lieselotte longs to be her friend. Lieselotte is also deeply in love with her own fiancé, Prince Siegwald Fitzenhagen—the game's main love interest. Unfortunately, in almost every route, Lieselotte is doomed to a tragic end. Kobayashi manages to convince Endou to play MagiKoi to practice his speaking skills. What begins as a normal playthrough turns extraordinary when Siegwald suddenly hears the players' voices inside the game! Now labeled as "gods," Endou and Kobayashi use their comments and analyses to save their beloved tsundere villainess from her fated demise.

In a shocking turn of events, humanity has won its first battle in the Ragnarök tournament—a series of 13 fights that will decide the fate of mankind. Zeus, the head of gods, sends the demigod Heracles for the next round to avenge the humiliated Greek pantheon. To face this hero loved by gods and humans alike, the Valkyrie Brunhilde decides to use Heracles' complete moral opposite: the infamous serial killer Jack the Ripper—leaving human beings unsure who they should support. Meanwhile, tensions begin to rise between various divine pantheons, and rumors of a traitor jeopardize the unity of those who want to annihilate humanity. As the line between friend and foe becomes blurred, Brunhilde will do everything she can to make her machinations successful.

Kiki, a 13-year-old witch-in-training, must spend a year living on her own in a distant town in order to become a full-fledged witch. Leaving her family and friends, Kiki undertakes this tradition when she flies out into the open world atop her broomstick with her black cat Jiji.

As she settles down in the coastal town of Koriko, Kiki struggles to adapt and ends up wandering the streets with no place to stay—until she encounters Osono, who offers Kiki boarding in exchange for making deliveries for her small bakery. Before long, Kiki decides to open her own courier service by broomstick, beginning her journey to independence. In attempting to find her place among the townsfolk, Kiki brings with her exciting new experiences and comes to understand the true meaning of responsibility.