Despite having a good reputation as one of the most seasoned guards in the local guild of Mebuki, Kikuru Madan believes he has been wasting his youth and hopes to spend the rest of it like any other person. However, his conscience prevents him from retiring at present, as he worries about the guild's future without him. Coincidentally—as if to help him find his successor—the guild's receptionist, Enome, assigns Kikuru four fresh recruits: the energetic beastwoman Hitamu "Hitamuki" Kyan, the prodigy Maidena Ange, the laid-back Toxico Dannar, and the stalwart Hanabata Nohkins. Although each of them possesses significant talents, they also display characteristics that detract from their potential—including Hitamu's extreme clumsiness and Hanabata's unintentional perverseness. As if there was not enough to deal with, the monsters outside Mebuki's walls start exhibiting odd behavior by targeting women salaciously, causing the party endless problems in more ways than one. Nevertheless, Kikuru is committed to retiring early; to achieve his goal, the guidance he gives the trainees will be absolutely essential.

The Yuzuki family, which consists of four brothers, lost their parents two years ago. Hayato, the eldest son, is a hard worker and the pillar of the family. Mikoto, the second son, is calm and collected, but he has a soft spot for his younger brother Minato, whom he adores and thinks is cute. Minato, the third son, is energetic and adores his brothers, but he is clumsy and awkward. Gakuto, the fourth son, is a studious and mature first-grader who is often referred to as a "wise man." The manga depicts the four brothers' daily lives as they navigate their family, school, and community.

While walking through the forest one day, a witch named Alyssa finds a bush glowing with a magical aura. She discovers a baby who, although not a witch, possesses magic that is too strong for that of a mere human. As such, Alyssa decides to raise the child as her own, naming her Viola. Sixteen years later, Viola is all grown up and now towers over her youthful mother, and her mature looks cause many to confuse their ages. Nevertheless, Alyssa adores her child despite Viola's possessive streak and tendency to drive away anyone she fears will take away her mother's love. Viola may not be sure where she came from, though she has all she needs in Alyssa and the plethora of Alyssa's friends who have come together to raise her. Under Alyssa's guidance, Viola will learn to master her magic and make her adoptive mother proud.

Former ace runner of Sendai Josei High School, Kakeru Kurahara is chased away from a convenience store for shoplifting. Shaking off his pursuer, he runs into Haiji Kiyose, another student from his university. Haiji is impressed by Kakeru's agility and persuades him to live in Chikusei-sou, the run-down apartment where Haiji resides along with eight other students. Having lost his entire apartment deposit at a mahjong parlor, Kakeru accepts the offer reluctantly. However, Haiji reveals a secret during Kakeru's welcoming party: the apartment is actually the dormitory of the Kansei University Track Club. He unveils his ultimate goal of participating in the Hakone Ekiden—one of the most prominent university marathon relay races in Japan. Unfortunately, all the residents apart from Haiji and Kakeru are complete running novices. Worse still, none of the inhabitants are even remotely interested in being involved with Haiji's ridiculous plan! With only months before the deadline, will the fourth-year student be able to convince them otherwise and realize his elusive dream of running in the Hakone Ekiden? [Written by MAL Rewrite]