Hitotose Chitose was always alone and untrusting of people but when 5 female teachers appear and started living together with him in his family's house as his mothers, things started to change and pick up, together with Hazuki-nee and Minazuki (his 2 sisters) everyday is a lesson.

Amawa Hibiki is a young man just out of college, with an education to be an athletics teacher. He's been having a hard time finding a job since he graduated, so all his money has gone towards living expenses. When his landlady demands his first payment to live in her living establishment upfront, he heads to the local middle school to get hired as a teacher. However, the principal refuses to hire him without hesitation. She will not hire men as teachers and makes it clear that she hates all men, saying they put no love into their passions and work. Amawa does not give up and with the help of his landlady, he crossdresses as a woman without a second thought, and gets hired, so he can earn money and also prove the principal wrong. Now, he has to keep his real gender a secret, and avoid strange situations, including the affections of his students (from both genders).

In the distant future, humanity has taken to the skies and colonized many planets throughout the universe. An agency known as the Galactic Organization of Trade and Tariffs (GOTT) has been formed to maintain order. Within GOTT, a secret squad of enhanced human beings—known as the ES Unit—carry out secret missions to put a stop to major galactic crimes. Two such operatives are the lowly C-ranked Éclair and Lumière. Despite being on the bottom of the totem pole, the pair wield formidable powers: Éclair's superhuman strength and lipstick whip and Lumière's ability to take control of any computer. Together, they can take on any mission that GOTT throws at them. But as they complete more and more missions, the duo begin to uncover a major conspiracy that leaves them questioning everything they know about themselves and the entire galaxy. [Written by MAL Rewrite]

Many years ago, humans and demons lived in harmony. But that unity ended when demons started attacking humans and plotted a mission to unleash Gyumao—an evil demon imprisoned for thousands of years. Now, Genjo Sanzo, a rogue priest, must team up with three demons—Sha Gojyo, Son Goku, and Cho Hakkai—and embark on a perilous journey to the west to stop these demons from resurrecting Gyumao and restore the balance between humans and demons on Earth.