More crazy antics abound as Nozomu Itoshiki (a.k.a Zetsubou-sensei), who is the worlds most negative person, tries to teach class 2-F about how life is filled with despair and darkness. A harder task than it first may seem, with his students being far from ordinary themselves, including the likes of the most positive girl he has ever met, his very own stalker, a foreign exchange student with split personalities and a perfectionist acting class president, due to the fact the real class president can't be seen by anyone, among others. (Source: ANN)

Zoids are beast-like fighting machines used in both everyday use such as transportation, and special use such as war. Some types of Zoids, know as Organoids, are miniature Zoids that are living organisms. These Organoids have the capability to fuse with a non-living Zoid and make it much more powerful. Van (Ban) Freiheit discovers a Zoid Organoid in an abandoned laboratory while running from two strangers piloting Zoids. Also in the laboratory, in an animated suspension tube is a strange girl. He breaks the tube open and takes her and the Organoid with him. Spotting a ruined Shield Liger Zoid outside nearby, the Organoid fuses with it and repairs the damages. Making his escape, Van names the Organoid Zeke, and decides to keep him as a friend. The girl, who says her name is Fiona, wants to find something called Zoids Eve, and so Van, Zeke, and Fiona begin their adventure. (Source: AniDB)

Everybody goes on vacation to Ayanokouji's private island for fun in the sun. Hilarity ensues.

Nozomu Itoshiki is still the bizarre teacher of the even stranger Class 2-F. He attempts to teach his students the negative aspects of the world and society, only to have each circumstance thrown at his face whenever he tries. With more students and friends than before, Zetsubo-sensei's life becomes harder and crazier than ever before. (Source: ANN)