Sena is like any other shy kid starting high school; he's just trying to survive. Constantly bullied, he's accustomed to running away. Surviving high school is about to become a lot more difficult after Hiruma, captain of the school's American football team, witnesses Sena's incredible agility and speed during an escape from some bullies. Hiruma schemes to make Sena the running back of his school team, The Devil Bats, hoping that it will turn around the squad's fortunes from being the laughingstock of Japan's high school leagues, to title contender. To protect his precious star player from rivaling recruiters, he enlists Sena as "team secretary," giving him a visored helmet and the nickname "Eyeshield 21" to hide his identity. The Devilbats will look to make their way to the Christmas Bowl, an annual tournament attended by the best football teams in Japan, with "Eyeshield 21" leading the way. Will they be able to win the Christmas Bowl? Will Sena be able to transform from a timid, undersized freshman to an all-star player? Put on your pads and helmet to find out!

Three years ago, a gateway between Earth and the Beyond opened in New York City, trapping extradimensional creatures and humans alike in an impermeable bubble. After the city's restoration, monsters, magic, and madness are common findings in the area now known as Hellsalem's Lot. Leonardo Watch, a young photographer who unwillingly obtained the "All-seeing Eyes of the Gods" in exchange for his sister's eyesight, came to this paranormal city to find answers to the mysterious power that he possesses. He later finds his life drastically changed when he joins Libra, a secret organization of people with supernatural abilities dedicated to maintaining order in the everyday chaos of Hellsalem's Lot. However, this is only the beginning of Leonardo's unexpected journey ahead. Regardless of the constant threat of otherworldly enemies, he is determined to uncover the secrets of his power and find a way to restore his sister's eyesight. Kekkai Sensen & Beyond follows Leonardo as he sets off on more crazy adventures with his comrades, fighting to ensure peace and order.

In celebration of 20 years of , Studio Pierrot posted an anniversary PV on their YouTube channel. The PV is a compilation of newly reworked scenes from containing new animation.

The story centers on Minato Kiyoumizu, a boy who quit playing water polo after an incident during the winter of his third year of junior high school. After entering high school, he makes a promise and decides to try water polo again and join the school's team with his friends. However, the new team will run into problems along the way... (Source: MAL News)