Megumin is a young and passionate wizard from the Crimson Demon Village, a remote community of mages with red eyes and a flair for the dramatic. She has devoted her life to mastering explosion magic, a powerful but impractical spell that leaves her drained of mana and unable to move for the rest of the day. Regardless, she refuses to learn any other skills. Along with her childhood friend and self-proclaimed rival, Yunyun, Megumin enrolls in the Red Prison: a prestigious academy for Crimson Demon magic users. There, she learns more about the secrets and history of her clan, as well as the threats and challenges they must face. As she polishes her power at the Red Prison with the help of her loyal familiar Chomusuke and her adorable little sister Komekko, Megumin aims to become the greatest explosion wizard of all time!

After a successful showdown at Tokyo Tower, the Mew Mew girls enjoy a temporary respite. Now that Ichigo Momomiya and Masaya Aoyama have confessed their feelings to each other, Ichigo is overjoyed to spend time with her new boyfriend. However, their quick break gets interrupted, and soon the girls must battle against the Chimera Anima yet again. When things go awry in the ensuing fight, Ichigo is placed in grave danger. Just when things look most bleak, the mysterious Blue Knight arrives and saves Ichigo, proclaiming that he was born to protect her, before disappearing into thin air. With the fate of the world on their shoulders and the identity of the Blue Knight in question, the Mew Mew girls must strive to create balance between alien-fighting and their personal lives.

In order to pursue her dream of bringing positive changes to Japan, Mitsumi Iwakura leaves her countryside town to attend a prestigious high school in the hustle and bustle of Tokyo. As she has already mapped a clear life plan, she has absolute confidence that there will be zero mishaps from then onwards. Despite her ambitious promise, the country girl ends up running late on the first day when she gets lost on her way to school. Fortunately, she meets a fellow first-year student, Sousuke Shima, who is in the same situation and offers to go with her. They eventually make it to school, but the misfortunes do not end there, as Mitsumi leaves an unfavorable first impression in front of her classmates. Nevertheless, the class soon takes notice of her friendship with Sousuke despite their opposing personalities. Only time will tell whether Mitsumi will be able to forge fruitful relationships with her classmates, and she will certainly not be alone.

Junta Shiraishi is a high school student with one simple goal—to enjoy his youth. However, achieving this goal is not so straightforward since Shiraishi is effectively invisible to his peers; even his teachers routinely fail to notice his presence. In fact, there is a rumor circulating that whoever manages to spot him will receive good luck. But there is one person who notices Shiraishi's presence without fail. Seated right next to him, Nagisa Kubo is determined not to let him quietly fade into the background. Unfortunately for him, this means that Shiraishi finds himself in some peculiar situations, all orchestrated by Kubo. Despite this, Kubo's playful antics might just be the catalyst needed to spark the thrilling youth that Shiraishi longs for.