What do an alien, former ninja, weak telepath, and boy pretending to be a girl have in common? They are all classmates at Kashihara Girls' Academy, and they hide their true identities from the world. Rikka, Chiyo, Sekine, and Tsubasa seem like the best of friends, but they each harbor a monumental secret that they cannot reveal, no matter what. In order to continue masquerading as normal middle school girls, each of them must invent creative ways to conceal their true selves. But that is easier said than done, as the four students end up entangled in numerous shenanigans along the way.

Unable to achieve the desired results on the first and second days of the Inter-High competition, members of the Souhoku High Bicycle Racing Club use their frustration as motivation to perform better on the final day of the race. However, it is easier said than done as they are up against the overwhelming talent of Hakone Academy and the shrewd strategies of Kyoto Fushimi High. Despite the challenge, Souhoku members are not disheartened by the obstacles that they need to overcome. After all, no matter what their opponents try, Souhoku will have the last laugh as long as they are the first to cross the finish line.

After her parents are killed by bandits, young Sarasa Feed is sent to an orphanage where she learns about the prestigious world of alchemy. Determined to follow in her late parents' footsteps and become an independent business owner, she enrolls at the Royal Alchemist Academy to train and get certified as an official alchemist. Five years later, Sarasa graduates from the institution and nearly achieves her dream before realizing that she lacks the funds to do so. Left with little choice, she makes do with a low-priced storefront in a town situated far away from the bustling capital. Despite the threat of treacherous terrain and dangerous monsters in the remote countryside, Sarasa begins her exciting new life as an alchemist.

In the land of Terra, natural disasters of unknown causes have been occurring irregularly in many areas. Therefore, the majority of the people, in order to escape those natural disasters, came to live in mobile cities developed over the years. The Originium left behind at the site of such Catastrophes, has led to the rapid progress of civilization due to their immense energy. But it also brought something else with it — an incurable disease called Oripathy. Because the bodies of those with Oripathy gradually crystalize and become a new source of infection at the time of death, in many countries, the Infected are subject to persecution under regimes of segregation and forced labor. Those who were oppressed by the governments are starting to rebel. Rhodes Island, a pharmaceutical company researching a cure for Oripathy, takes up their arms and starts a conquest trying to save all the people from the disease.